The first study comparing Mounjaro (tirzepatide) and Wegovy (semaglutide) suggests that Mounjaro may be more effective for weight loss, achieving an average reduction of 20% of body weight compared to Wegovy’s 14% after 72 weeks of treatment. We've summarised some key takeaways from the study:
Trial Highlights:
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Weight Loss:
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Mounjaro: 20% weight reduction on average.
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Wegovy: 14% weight reduction on average.
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32% of Mounjaro users lost a quarter of their body weight, compared to 16% of Wegovy users.
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Waistline Reduction:
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Mounjaro: 18 cm average reduction.
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Wegovy: 13 cm average reduction.
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Health Benefits:
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Mounjaro showed better improvements in blood pressure, blood sugar, and cholesterol levels compared to Wegovy.
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Side Effects:
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Both drugs had similar levels of side effects.
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Gender Differences:
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Women tended to lose more weight compared to men.
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Mechanism of Action:
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Wegovy (semaglutide): Mimics a hormone that signals fullness after eating.
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Mounjaro (tirzepatide): Acts on two hormonal pathways for appetite suppression, making it more effective.
Clinical Context:
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The trial was funded by Eli Lilly, the manufacturer of Mounjaro.
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Conducted on 750 obese individuals with an average weight of 113 kg.
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Presented at the European Congress on Obesity and published in the New England Journal of Medicine.
Market and Usage:
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In the UK, both drugs are available through specialist weight-management services and private purchase.
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Private sales of tirzepatide (Mounjaro) are significantly higher than semaglutide (Wegovy).
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Wegovy is also licensed for preventing heart attacks, while Mounjaro is not.
Future Outlook:
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The landscape of weight-loss treatments is evolving, with ongoing research into:
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Higher doses of current drugs.
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Oral administration options.
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New medicines targeting different metabolic pathways.
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The study’s findings suggest that while Wegovy remains a viable option, Mounjaro may be preferable for those needing significant weight reduction. However, further studies, especially on long-term cardiovascular outcomes, are needed for a more comprehensive comparison.
Happy Pharmacy will keep you posted on future developments in our Blogs. Come and find out more about Weight Loss options with us Weight Loss Injectables & Weight Loss Capsules | Happy Pharmacy
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