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The first study comparing Mounjaro (tirzepatide) and Wegovy (semaglutide) suggests that Mounjaro may be more effective for weight loss, achieving an average reduction of 20% of body weight compared to Wegovy’s 14% after 72 weeks of treatment. We've summarised some key takeaways from the study:

Trial Highlights:

  • Weight Loss:

    • Mounjaro: 20% weight reduction on average.

    • Wegovy: 14% weight reduction on average.

    • 32% of Mounjaro users lost a quarter of their body weight, compared to 16% of Wegovy users.

  • Waistline Reduction:

    • Mounjaro: 18 cm average reduction.

    • Wegovy: 13 cm average reduction.

  • Health Benefits:

    • Mounjaro showed better improvements in blood pressure, blood sugar, and cholesterol levels compared to Wegovy.

  • Side Effects:

    • Both drugs had similar levels of side effects.

  • Gender Differences:

    • Women tended to lose more weight compared to men.

Mechanism of Action:

  • Wegovy (semaglutide): Mimics a hormone that signals fullness after eating.

  • Mounjaro (tirzepatide): Acts on two hormonal pathways for appetite suppression, making it more effective.

Clinical Context:

  • The trial was funded by Eli Lilly, the manufacturer of Mounjaro.

  • Conducted on 750 obese individuals with an average weight of 113 kg.

  • Presented at the European Congress on Obesity and published in the New England Journal of Medicine.

Market and Usage:

  • In the UK, both drugs are available through specialist weight-management services and private purchase.

  • Private sales of tirzepatide (Mounjaro) are significantly higher than semaglutide (Wegovy).

  • Wegovy is also licensed for preventing heart attacks, while Mounjaro is not.

Future Outlook:

  • The landscape of weight-loss treatments is evolving, with ongoing research into:

    • Higher doses of current drugs.

    • Oral administration options.

    • New medicines targeting different metabolic pathways.

The study’s findings suggest that while Wegovy remains a viable option, Mounjaro may be preferable for those needing significant weight reduction. However, further studies, especially on long-term cardiovascular outcomes, are needed for a more comprehensive comparison.  

Happy Pharmacy will keep you posted on future developments in our Blogs.  Come and find out more about Weight Loss options with us Weight Loss Injectables & Weight Loss Capsules | Happy Pharmacy

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